Laboratory for Molecular Photonics
Department of Chemistry
University of Miami
Goal: The goal of this project is the development of activatable fluorophores designed to permit the selective detection of cancer cells with intense signals against dark backgrounds.
Results: The Laboratory of Molecular Photonics develops activatable macromolecular probes designed to switch their bright fluorescence on exclusively within the acidic organelles of cancer cells.
Keywords: Borondipyrromethenes Cancer Detection Coumarins Fluorescence Halochromism Macromolecular Probes Molecular Switches Oxazines Polymers
The selective internalization of pH-
"Highlighting Cancer Cells with Halochromic Switches": S. Tang, Y. Zhang, E. R. Thapaliya, A. Brown, J. N. Wilson, F. M. Raymo, ACS Sens., 2017, 2, 92–101
"Bioimaging with Macromolecular Probes Incorporating Multiple BODIPY Fluorophores": E. R. Thapaliya, Y. Zhang, P. Dhakal, A. S. Brown, J. N. Wilson, K. M. Collins, F. M. Raymo, Bioconjugate Chem., 2017, 28, 1519–1528
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