Laboratory for Molecular Photonics

Department of Chemistry

University of Miami

Selected Articles

  "Supramolecular Strategies to Construct Biocompatible and Photoswitchable Fluorescent Assemblies": I. Yildiz, S. Impellizzeri, E. Deniz, B. McCaughan, J. F. Callan, F. M. Raymo, J. Am. Chem. Soc., 2011, 133, 871–879

  "Intracellular Guest Exchange Between Dynamic Supramolecular Hosts": S. Swaminathan, C. Fowley, B. McCaughan, J. Cusido, J. F. Callan, F. M. Raymo, J. Am. Chem. Soc. 2014, 136, 7907–7913

  "Supramolecular Nanoreactors for Intracellular Singlet-Oxygen Sensitization": S. Swaminathan, C. Fowley, E. R. Thapaliya, B. McCaughan, S. Tang, A. Fraix, B. Captain, S Sortino, J. F. Callan, F. M. Raymo, Nanoscale 2015, 7, 14071–14079

 "Energy-Transfer Schemes to Probe Fluorescent Nanocarriers and Their Emissive Cargo": E. R. Thapaliya, C. Fowley, B. Callan, S. Tang, Y. Zhang, J. F. Callan, F. M. Raymo, Langmuir, 2015, 31, 9557–9565

Selected Reviews

  "Photoresponsive Polymer Nanocarriers with Multifunctional Cargo": S. Swaminathan, J. Garcia-Amorós, A. Fraix, N. Kandoth, S. Sortino, F. M. Raymo, Chem. Soc. Rev. 2014, 43, 4167–4178

  "Self-Assembling Nanoparticles of Amphiphilic Polymers for in Vitro and in Vivo FRET Imaging": J. Garcia-Amorós, S. Tang, Y. Zhang, E. R. Thapaliya, F. M. Raymo, Top. Curr. Chem. 2016, 137, 29–59

Goal: The goal of this project was the identification of viable strategies to transport photoresponsive molecules inside living cells and operate them in the intracellular space under optical control.

Results: The Laboratory of Molecular Photonics developed self-assembling nanoparticles of amphiphilic polymers capable of encapsulating hydrophobic chromophores in their interior and deliver their photoresponsive cargo unaffected inside living cells.

Keywords: Amphiphilic Polymers Energy Transfer Fluorescence Intracellular Transport Nanoparticles Self-Assembly

Self-assembling nanoparticles transport donors and acceptors inside cells and allow the transfer of energy to occur exclusively in the intracellular space