Laboratory for Molecular Photonics

Department of Chemistry

University of Miami

Goal: The goal of this project is the development of photoactivatable fluorophores designed to permit the monitoring of dynamic events in real time within living organisms.

Results: The Laboratory of Molecular Photonics develops self-assembling nanoparticles capable of delivering photoactivatable fluorophores in selected locations within developing embryos and allow the subsequent monitoring of dynamic events with fluorescence measurements.

Keywords: Borondipyrromethenes Dynamics Fluorescence Photocages Molecular Switches Photoactivatable Fluorophores Oxazines

Selected Articles

  "Photoactivatable BODIPYs Designed to Monitor the Dynamics of Supramolecular

     Nanocarriers": Y. Zhang, S. Swaminathan, S. Tang, J. Garcia-Amorós, M. Boulina, B. Captain, J. D. Baker, F. M. Raymo, J. Am. Chem. Soc. 2015, 137, 4709–4719

 "Optical Writing and Reading with a Photoactivatable Carbazole": J. Garcia-Amorós, S. Swaminathan, Y. Zhang, S. Nonell, F. M. Raymo, Phys. Chem. Chem. Phys., 2015, 17, 11140–11143

  "Supramolecular Delivery of Fluorescent Probes in Developing Embryos": Y. Zhang, E. R. Thapaliya, S. Tang, J. D. Baker, F. M. Raymo, RSC Advances, 2016, 6, 72756–72760

  "A Photoswitchable Fluorophore for the Real-Time Monitoring of Dynamic Events in Living Organisms": Y. Zhang, S. Tang, L. Sansalone, J. D. Baker, F. M. Raymo, Chem. Eur. J., 2016, 22, 15027–15034

Selected Reviews

"Photoactivatable Fluorophores": F. M. Raymo, ISRN Phys. Chem., 2012, 619251-1–15

"Photoactivatable Synthetic Fluorophores": F. M. Raymo, Phys. Chem. Chem. Phys., 2013, 15, 14840–14850

The irreversible photoactivation of a borondipyrromethene fluorophore with the photocleavage of an oxazine ring allows the real-time monitoring of dynamic events in developing Drosophila melanogaster embryos.