Laboratory for Molecular Photonics


Department of Chemistry

University of Miami

Goal: The goal of this project was the identification of operating principles to signal the presence of target analytes with significant changes in the absorption wavelength or emission intensity of sensitive chromophores.


Results: The Laboratory of Molecular Photonics developed silica nanoparticles coated with fluorescent diazapyrenium dications to sense the neurotransmitter dopamine, a protocol to probe pH with semiconductor quantum dots coated with chromogenic oxazines, a mechanism to identify ligands for target proteins with supramolecular assemblies of bipyridinium dications and quantum dots, a strategy to detect the toxic cyanide anion with chromogenic oxazines.




Keywords: Chemosensors Cyanide Dopamine Fluorescence Nanoparticles Oxazines pH Sensors Proteins Ligand Screening Quantum Dots Viologens


Selected Articles

  "Fluorescent Diazapyrenium Films and Their Response to Dopamine": M. A. Cejas, F. M. Raymo, Langmuir, 2005, 21, 5795–5802.

  "A pH-Sensitive Ligand for Luminescent Quantum Dots": M. Tomasulo, I. Yildiz, S. L Kaanumalle, F. M. Raymo, Langmuir, 2006, 22, 10284–10290.

  "A Mechanism to Signal Receptor–Substrate Interactions with Luminescent Quantum Dots": I. Yildiz, M. Tomasulo, F. M. Raymo, Proc. Natl. Acad. Sci. USA, 2006, 103, 11457–11460.

  "Chromogenic Oxazines for Cyanide Detection": M. Tomasulo, S. Sortino, A. J P. White, F. M. Raymo, J. Org. Chem., 2006, 71, 744–753


Patents

  "Colorimetric Detection of Cyanide with a Chromogenic Oxazine": F. M. Raymo, M. Tomasulo, U.S. Pat. 8,198,436: June 12, 2012

  "Mechanism to Signal Protein–Ligand Interactions with Luminescent Quantum Dots": F. M. Raymo, M. Tomasulo, I. Yildiz, U.S. Pat. 8,198,099: June 12, 2012


Selected Reviews

  "Luminescent Chemosensors Based on Semiconductor Quantum Dots": F. M. Raymo, I. Yildiz, Phys. Chem. Chem. Phys., 2007, 9, 2036–2043

  "Electron and Energy Transfer Mechanisms to Switch the Luminescence of Semiconductor Quantum Dots": I. Yildiz, M. Tomasulo, F. M. Raymo, J. Mater. Chem., 2008, 18, 5577–5584

Chromogenic oxazines respond to micromolar concentrations of the toxic cyanide anion with a pronounced change in color.