208 Cox Science Center
1301 Memorial Drive, Coral Gables, FL 33124
- (305) 284-4134
- (305) 284-3039
- (305) 284-1676
Education and Professional Experience
- 2011-Present, Co-Instructor, Embryology: Concepts & Techniques in Modern Developmental Biology, Marine Biological Laboratory, Woods Hole, MA
- 2009-Present, Editorial Board, EvoDevo
- 2009-Present, Professor, Department of Biology, The University of Miami
- 2007-2009, Associate Professor, Department of Biology, The University of Miami
- 2005-2007, Associate Professor of Zoology (with tenure), University of Hawaii at Manoa
- 2005, The National Academies Summer Institutes on Undergraduate Education in
Biology, University of Wisconsin-Madison
- 2004-2005, President, Sigma Xi University of Hawaii at Manoa chapter
- 2001-2005 Assistant Professor of Zoology, University of Hawaii at Manoa
- 1998-2000, Assistant Professor of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center.
- 1997-1998, Research Associate: Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center.
- 1993-1997, Postdoctoral Fellow: Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center
- 1993, Ph.D. in Zoology, University of California, Davis
Awards and Recognition
- National Academies Education Fellow in the Life Sciences, 2005-2006
- Outstanding Biology Educator, Department of Biology, University of Miami, 2012
NIH 1R03HD068672-01A1. Regulators of Dishevelled Function in the Wnt Signaling Pathway. August 8, 2012 - July 31, 2014
National Science Foundation. Evolution of embryonic polarity: The role of the Wnt signaling pathways.July 1, 2007- July 30 2011)
National Science Foundation. Specification and patterning of the animal-vegetal axis. January 1, 2005-December 31, 2008
Areas of Focus
Developmental Biology; Evolutionary Biology
I am an evolutionary developmental biologist and my laboratory uses embryological, molecular, genomic and phylogenetic approaches to investigate the evolution of pattern formation in metazoan embryos. A major focus of my laboratory is to investigate the molecular basis for the evolution, specification and patterning of the animal-vegetal (AV) axis. The AV axis is a cytoplasmic/cytoarchitectural polarity that is present in most animal eggs, and is specified maternally by largely unknown mechanisms. This maternally deposited developmental information is used during embryogenesis to specify the primary germ layers. We use embryos of sea urchins, which are basal deuterostomes from the phylum Echinodermata, as a model system for our studies on AV axis specification and patterning. In parallel with these studies in sea urchins, we use this information in a phylogenetic context to gain insight into the mechanisms that may have led to the evolution of the AV axis and the evolution of the germ layers. For these comparative studies we use the new genomic cnidarian model system, Nematostella vectensis. Cnidarians are thought to be the sister group to the bilaterians, making Nematostella an excellent model system for gaining insight into the conserved developmental mechanisms shared by the last common ancestor to bilaterians and cnidarians. This phylogenetic approach has yielded important insight into the evolutionarily conserved role of the Wnt signaling pathway in early pattern formation in animal embryos. Additionally, these simple marine invertebrate embryos are proving to be excellent model systems for studying the regulation and evolution of the Wnt pathway, a pathway of considerable biomedical significance.
In the fall semester I teach one of the Introductory Biology HHMI labs that involves freshman students in active learning through research projects. In the spring semester I teach Developmental Biology to undergraduate and graduate students, and the Biology Honors Symposium. I also teach a module in the Biology Core Curriculum for graduate students.
- Kumburegama, S., Wijesena, N., Xu, X and Wikramanayake, A.H. (2011). Strabismus-mediated primary archenteron invagination is uncoupled from Wnt/beta-catenin-dependent endoderm cell fate specification in Nematostella vectensis (Anthozoa, Cnidaria): Implications for the evolution of gastrulation. EvoDevo 2:2 (Highly accessed; Evaluated by Faculty of 1000).
- Byrum, C.A., Xu, R, Bince, J, McClay, D.R., and Wikramanayake, A.H. (2009). Blocking Dishevelled signaling in the non-canonical Wnt pathway in sea urchins disrupts endoderm formation and spiculogenesis, but not secondary mesoderm formation. Dev. Dynamics 238, 1649-1665
- Lee, P., Kumburegama, S., Marlowe, H., Martindale, M.Q. and Wikramanayake, A.H. (2007). Asymmetric developmental potential along the animal-vegetal axis in the anthozoan cnidarian, Nematostella vectensis, is mediated by Disheveled. Dev. Biol. 310, 169-186.
- Wikramanayake, A.H., Hong, M., Lee, P.N., Pang, K., Byrum, C.A., Bince, J.M., Xu, R. and M.Q. Martindale. (2003). An ancient role for nuclear beta-catenin in the evolution of axial polarity and germ layer segregation. Nature 426, 446-450 (Evaluated by Faculty of 1000)
- Wessel, G.M. and A.H. Wikramanayake. (1999). How to grow a gut: Ontogeny of the endoderm in the sea urchin embryo. BioEssays, 21, 459-471.
- Wikramanayake, A.H. , Huang, L. and W. H. Klein. (1998). beta-catenin is essential for patterning the maternally specified animal-vegetal axis in the sea urchin embryo. Proc. Natl. Acad. Sci. USA 95, 9343-9348.